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Antimicrob Agents Chemother. 1997 Sep;41(9):2016-8.

VanD-type glycopeptide-resistant Enterococcus faecium BM4339.

Author information

  • 1Unité des Agents Antibactériens, Institut Pasteur, Paris, France. brunoper@pasteur.fr

Abstract

Enterococcus faecium BM4339 was constitutively resistant to vancomycin (MIC, 64 microg/ml) and to low levels of teicoplanin (MIC, 4 microg/ml). A 605-bp product obtained with the V1 and V2 primers for amplification of genes encoding D-Ala:D-Ala ligases and related glycopeptide resistance proteins was sequenced after cloning. The deduced amino acid sequence had 69% identity with VanA and VanB and 43% identity with VanC, consistent with the finding that BM4339 synthesized peptidoglycan precursors terminating in D-lactate. This new type of glycopeptide resistance phenotype was designated VanD.

PMID:
9303405
PMCID:
PMC164056
[PubMed - indexed for MEDLINE]
Free PMC Article
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