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Trends Biochem Sci. 1997 Sep;22(9):345-9.

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation.

Author information

1
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908, USA.

Abstract

Insulin and growth factors elicit rapid increases in protein synthesis by stimulating mRNA translation. PHAS/4E-BPs, a recently discovered family of elF4E-binding, proteins, appear to play a key role in this process, as well as in the control of cell proliferation.

PMID:
9301335
DOI:
10.1016/s0968-0004(97)01101-8
[Indexed for MEDLINE]

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