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Trends Biochem Sci. 1997 Sep;22(9):334-9.

Lac repressor genetic map in real space.

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  • 1Department of Chemistry, University of Pennsylvania, Philadelphia, USA.


Here, we present a graphic display of the phenotypes of more than 4000 single amino acid substitution mutations on the three-dimensional structure of the lac repressor tetramer bound to DNA. The genetic data and the X-ray diffraction studies contribute to define an allosteric mechanism and yield a visual demonstration of the importance of core or buried residues in protein structure.

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