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Pharm World Sci. 1997 Aug;19(4):159-75.

Clinical pharmacology of HIV protease inhibitors: focus on saquinavir, indinavir, and ritonavir.

Author information

1
Department of Pharmacy & Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands.

Abstract

In this review the clinical pharmacology of HIV protease inhibitors, a new class of antiretroviral drugs, is discussed. After considering HIV protease function and structure, the development of inhibitors of HIV protease is presented. Three protease inhibitors are reviewed in more detail: saquinavir, indinavir, and ritonavir. Clinical trial results with these agents are evaluated. Furthermore, adverse effects, resistance, dosage and administration, clinical pharmacokinetics, pharmacokinetic-pharmacodynamic relationships, and drug interactions are discussed.

PMID:
9297727
[Indexed for MEDLINE]

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