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Curr Genet. 1997 Aug;32(2):100-7.

Cold-sensitive rad52 alleles of yeast.

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1
Department of Biochemistry, University of Minnesota, 435 Delaware St. SE, Minneapolis, MN 55455-0347, USA.

Abstract

We have characterized two rad52 mutations that are cold-sensitive for growth on MMS agar. The mutations change residues 61 and 69, respectively, in the 504 amino-acid open reading frame. Neither mutation has a profound effect on mitotic crossing-over or on gene conversion. One has a severe deficiency in sporulation at all temperatures, while the other has a partial deficiency and reduced spore viability. Both mutants are retarded in growth on MMS agar by a high-copy plasmid expressing RAD51.

PMID:
9294257
[Indexed for MEDLINE]
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