Format

Send to

Choose Destination
Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10249-54.

Calx, a Na-Ca exchanger gene of Drosophila melanogaster.

Author information

1
Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

We have cloned Calx, a gene that encodes a Na-Ca exchanger of Drosophila melanogaster. Calx encodes two repeated motifs, Calx-alpha and Calx-beta, that overlap domains required for exchanger activity and regulation. Calx has multiple transcripts in adults, including at least one expressed in the retina. The Calx genomic locus comprises >/=35 kb between the Atpalpha and rudimentary-like genes in chromosomal region 93B. In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+ exchanger of mammalian heart. Implications of Calx-alpha motifs for the mechanism of Na-Ca exchange are discussed.

PMID:
9294196
PMCID:
PMC23348
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center