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Biochim Biophys Acta. 1997 Aug 7;1353(2):98-102.

Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut.

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  • 1Department of Molecular Medicine, Institute of Liver Studies, King's College School of Medicine and Dentistry, Camberwell, London, UK.


Human GATA-6 has been cloned from foetal heart by a combination of PCR-based methods and cDNA library screening. The 3.8 kbp cDNA has a coding sequence of 1347 bp the 449 aa protein is virtually identical in the two zinc-finger binding domains to other human GATA sequences, but varies considerably in the amino and carboxy terminal regions. The sequence shows greatest similarity to GATA-6-like sequences from rat, mouse, chicken and Xenopus. Northern analysis and in situ hybridisation show that GATA-6 is expressed at high levels in human adult and foetal heart as well as in gut derivatives. It is postulated that GATA-6, in concert with GATA-4, plays a crucial role in the regulation of cardiac differentiation.

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