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Immunol Today. 1997 Sep;18(9):450-4.

Replicative senescence of T cells: does the Hayflick Limit lead to immune exhaustion?

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Dept of Pathology and Laboratory Medicine, UCLA School of Medicine 90095-1732, USA.


Extensive in vitro research on fibroblasts has defined numerous genetic and phenotypic changes associated with replicative senescence. Identification of T-cell replicative senescence as a feature of human immunodeficiency virus (HIV) disease and ageing suggests this phenomenon merits more careful consideration by immunologists, especially with regard to chronic infection, memory and adoptive immunotherapy.

[Indexed for MEDLINE]

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