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J Oral Rehabil. 1997 Aug;24(8):594-604.

Effects of salivary or serum pellicles on the Candida albicans growth and biofilm formation on soft lining materials in vitro.

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Department of Prosthetic Dentistry, Hiroshima University School of Dentistry, Japan.


The effects of salivary or serum pellicle on Candida albicans growth, biofilm formation and cavitation on the soft lining materials were examined. Both saliva and serum pellicles reduced the antifungal effects of soft liners. The fungal biofilm formation on these materials varied depending upon both the materials tested and protein-coats, and the pellicles which significantly enhanced the biofilm formation. Similarly, the pellicles enhanced the firm colonization and hyphal invasion of the yeasts on the specimens, although the cavitation appeared to be regulated by the plasticizer used. These results suggest that the interactions between proteinaceous pellicle, tissue conditioners and fungi are complex. They also suggest that denture pellicles facilitate fungal plaque formation onto soft lining materials through several mechanisms such as reduction of the antifungal effects of soft liners, facilitation of biofilm formation, firm colonization and hyphal invasion. In addition, the composition of the materials is also involved in the susceptibility to the fungi.

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