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Surg Neurol. 1997 Sep;48(3):261-6.

Isolated deep cerebral venous thrombosis treated by direct endovascular thrombolysis.

Author information

1
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pennsylvania, USA.

Abstract

BACKGROUND:

Isolated thrombosis of the deep cerebral venous system is very rare and is associated with a poor prognosis. Antithrombin III (AT III) deficiency is a disorder of hypercoagulability associated with deep venous thrombosis and recurrent pulmonary emboli. We report a case of an 18-year-old man who presented with spontaneous thrombosis of the deep cerebral veins and straight dural sinus as the initial presentation of a previously undiagnosed AT III deficiency.

METHODS:

The patient was managed using direct endovascular infusion of the fibrinolytic agent urokinase followed by intravenous heparin.

RESULTS:

The technique was successful in establishing patency of the deep cerebral venous system. The patient experienced a good clinical outcome.

CONCLUSIONS:

Direct endovascular thrombolysis is a potentially effective management strategy for isolated thrombosis of the deep cerebral venous system.

PMID:
9290713
DOI:
10.1016/s0090-3019(96)00554-x
[Indexed for MEDLINE]

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