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J Nat Prod. 1997 Aug;60(8):842-3.

Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B.

Author information

1
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Republic of China.

Abstract

The structure of a metabolite produced on incubation of territrem B (1) with rat liver microsomes has been established to be 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B (5). Compound 5 was a potent inhibitor of electric eel acetylcholinesterase (AChE) (E.C. 3.1.1.7).

PMID:
9287420
DOI:
10.1021/np9701236
[Indexed for MEDLINE]

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