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Curr Opin Immunol. 1997 Aug;9(4):563-7.

Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis.

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Regional Primate Research Center, Department of Microbiology, University of Washington Medical Center, Seattle, WA 98195, USA.


Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.

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