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Curr Opin Immunol. 1997 Aug;9(4):491-7.

The CD40-CD154 system in anti-infective host defense.

Author information

1
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Abstract

Research in the past few years has documented significant advances in our understanding of the CD40-CD40 ligand (CD154) system in diverse immune functions. This system influences many T cell mediated inflammatory immune responses and effector functions, unmasking a previously unexpected role for CD40-CD154 in cell mediated immunity. Manipulation of CD154 in animal models of infection by the use of CD154-deficient mice or anti-CD154 antibodies has shown the importance of this system in the initiation of the inflammatory response, in the activation of antigen-presenting cells and in resistance to infections.

PMID:
9287184
[Indexed for MEDLINE]

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