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Psychiatr Genet. 1997 Summer;7(2):83-5.

Association between schizophrenia and a microsatellite polymorphism at the dopamine D5 receptor gene.

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Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, UK.


An association study of 97 patients with DSM-III-R schizophrenia and 97 matched controls was performed using a polymorphic microsatellite repeat at the dopamine D5 receptor gene. We observed a significant difference between the allele frequencies of patients and controls (chi 2 = 23.4, df = 12, p = 0.019). This reflects an excess of allele 4 (140 bp) in the patients when compared with the control sample (chi 2 = 7.087, p < 0.01; odds ratio = 2.98, 95% CI 1.29-6.86). However, this association remains tentative until confirmation in other samples.

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