Actions of FMRFamide-related peptides on the gCa2+ of the C1 neuron in Helix aspersa

Peptides. 1997;18(6):909-11. doi: 10.1016/s0196-9781(97)00010-7.

Abstract

The endogenous neuropeptides FMRFamide and FLRFamide (tetrapeptides) reversibly reduced a voltage-activated calcium current in the C1 neuron of Helix aspersa by an average of 20%. Two structurally related heptapeptides, pQDPFLRFamide and pQDPFLRIamide, both derived from another precursor protein in this species, did not reduce the current at all.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium Channels / drug effects*
  • Calcium Channels / metabolism
  • Enkephalin, Methionine / analogs & derivatives
  • Enkephalin, Methionine / pharmacology
  • Evoked Potentials / drug effects
  • FMRFamide / analogs & derivatives*
  • FMRFamide / pharmacology
  • Helix, Snails
  • Neurons / drug effects*
  • Neurons / metabolism
  • Neuropeptides / pharmacology
  • Oligopeptides / pharmacology
  • Pyrrolidonecarboxylic Acid / analogs & derivatives

Substances

  • Calcium Channels
  • Neuropeptides
  • Oligopeptides
  • Enkephalin, Methionine
  • FMRFamide
  • enkephalin-Met, Arg(6)-PheNH2(7)-
  • phenylalanyl-leucyl-arginyl phenylalaninamide
  • pyroglutamyl-aspartyl-prolyl-phenylalanyl-leucyl-arginyl-phenylalaninamide
  • Pyrrolidonecarboxylic Acid