Abstract
The endogenous neuropeptides FMRFamide and FLRFamide (tetrapeptides) reversibly reduced a voltage-activated calcium current in the C1 neuron of Helix aspersa by an average of 20%. Two structurally related heptapeptides, pQDPFLRFamide and pQDPFLRIamide, both derived from another precursor protein in this species, did not reduce the current at all.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Calcium Channels / drug effects*
-
Calcium Channels / metabolism
-
Enkephalin, Methionine / analogs & derivatives
-
Enkephalin, Methionine / pharmacology
-
Evoked Potentials / drug effects
-
FMRFamide / analogs & derivatives*
-
FMRFamide / pharmacology
-
Helix, Snails
-
Neurons / drug effects*
-
Neurons / metabolism
-
Neuropeptides / pharmacology
-
Oligopeptides / pharmacology
-
Pyrrolidonecarboxylic Acid / analogs & derivatives
Substances
-
Calcium Channels
-
Neuropeptides
-
Oligopeptides
-
Enkephalin, Methionine
-
FMRFamide
-
enkephalin-Met, Arg(6)-PheNH2(7)-
-
phenylalanyl-leucyl-arginyl phenylalaninamide
-
pyroglutamyl-aspartyl-prolyl-phenylalanyl-leucyl-arginyl-phenylalaninamide
-
Pyrrolidonecarboxylic Acid