Cell polarity: par for the polar course

Curr Biol. 1997 Sep 1;7(9):R562-4. doi: 10.1016/s0960-9822(06)00282-x.

Abstract

The nematode PAR-1 gene is required for asymmetric cell divisions during development. Recently identified mammalian Par-1 homologues are kinases that phosphorylate microtubule-associated proteins; their overexpression disrupts the microtubule cytoskeleton, and alters cellular structure and organization.

Publication types

  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans
  • Cell Polarity*
  • DNA-Binding Proteins / physiology*
  • Models, Biological
  • Saccharomyces cerevisiae Proteins*
  • Transcription Factors / physiology*

Substances

  • DNA-Binding Proteins
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
  • YAP1 protein, S cerevisiae