Abstract
The nematode PAR-1 gene is required for asymmetric cell divisions during development. Recently identified mammalian Par-1 homologues are kinases that phosphorylate microtubule-associated proteins; their overexpression disrupts the microtubule cytoskeleton, and alters cellular structure and organization.
MeSH terms
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Animals
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Caenorhabditis elegans
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Cell Polarity*
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DNA-Binding Proteins / physiology*
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Models, Biological
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Saccharomyces cerevisiae Proteins*
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Transcription Factors / physiology*
Substances
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DNA-Binding Proteins
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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YAP1 protein, S cerevisiae