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J Int Med Res. 1997 Jul-Aug;25(4):214-8.

Fluconazole treatment of neonates and infants with severe fungal infections.

Author information

1
Department of Paediatric Surgery, Uludağ University Medical Faculty, Bursa, Turkey.

Abstract

A total of 24 neonates and infants, aged from 2 days to 10 months, received treatment with intravenous fluconazole for microbiologically documented or presumed fungal infection. The mean fluconazole dosage was 6 mg/kg/day (range 2-16 mg/kg/day) and the mean duration of therapy was 25 days (range 5-72 days). Efficacy was evaluated in neonates with proven fungal infections, as documented by the presence of pathogen at baseline. A positive clinical response was achieved in 23 of the 24 clinically evaluable patients (96%); eradication of the fungal organism was also achieved in 23 of the 24 evaluable patients (96%). Adverse events occurred in two patients (8%) but therapy was not discontinued in either patient. The present results confirm the efficacy and safety of fluconazole in the treatment of neonates and infants with severe fungal infections.

PMID:
9283996
DOI:
10.1177/030006059702500408
[Indexed for MEDLINE]

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