Format

Send to

Choose Destination
Chem Biol. 1997 Aug;4(8):561-7.

Protein templates for the biosynthesis of peptide antibiotics.

Author information

1
Biochemie/Fachbereich Chemie, Hans-Meerwein-Strasse, Philipps-Universit├Ąt Marburg, 35032, Marburg, Germany. marahiel@ps1515.chemie.uni-marburg.de

Abstract

Peptide synthetases of microbial origin can act as protein templates for the biosynthesis of unusual, often pharmacologically active, peptides of diverse structure and biological activity. Specific repeated modules in the synthetases each contain at least two distinct domains, required for substrate adenylation and thiolation, that define the sequence and length of the peptide product. The first crystal structure of an adenylation domain has provided insights into the mechanism of substrate recognition and activation.

PMID:
9281530
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center