Send to

Choose Destination
J Cataract Refract Surg. 1996;22 Suppl 1:863-8.

Inhibition of migrating lens epithelial cells by sustained release of ethylenediaminetetraacetic acid.

Author information

Nishi Eye Hospital, Osaka, Japan.



To evaluate the effect of the sustained-release of ethylenediaminetetraacetic acid (EDTA) chelating Ca++ on lens epithelial cell (LEC) migration.


Nishi Eye Hospital, Jinshikai Medical Foundation, Osaka, Japan.


Polylactic-glycolic acid disks containing 10% EDTA were placed in saline solution for about 2 weeks in vitro. About 60% (7 micrograms/hour) of the EDTA was released during that time. The disks with a posterior chamber intraocular lens placed above were implanted in the capsular bag in five rabbit eyes after continuous curvilinear capsulorhexis and phacoemulsification. A disk without EDTA and the same lens type were placed in the bag in the contralateral eyes, which served as controls.


After 2 to 3 months, opacification in the central posterior capsule was significantly reduced in all eyes that received the disk with EDTA.


The deprivation of Ca++ disrupted interaction between the posterior capsule and migrating LECs by inactivating the adhesion molecule integrin synthesized by LECs, significantly reducing LEC migration onto the posterior capsule.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center