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Toxicon. 1997 Aug;35(8):1351-6.

Toxic properties of Beauveria pigments on erythrocyte membranes.

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1
Department of Applied Microbiology and Food Science, University of Saskatchewan, Saskatoon, Canada.

Abstract

The Beauveria pigments, tenellin, bassianin and oosporein, all inhibited total erythrocyte membrane ATPase activity in a dose-dependent manner by as much as 50% at 200 micrograms/ml. These pigments inhibited Ca(2+)-ATPases to a greater extent than Na+/K(+)-ATPase activity. The ATPase inhibitory activity for these pigments was not specific but was probably a consequence of membrane disruption, since pigments all caused alterations in erythrocyte morphology and promoted varying degrees of cell lysis.

PMID:
9278984
[Indexed for MEDLINE]
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