Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neuropsychiatry Clin Neurosci. 1997 Summer;9(3):460-70.

The medial temporal lobe in schizophrenia.

Author information

1
Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA. alveus@mail.med.upenn.edu

Abstract

Evidence from diverse avenues of research has highlighted abnormalities in the anatomy, physiology, and function of medial temporal lobe structures in schizophrenia. Clinical similarities between schizophrenia and psychotic disorders associated with temporal lobe lesions have been recognized for decades. Neuropsychological studies have found selective impairments in learning and memory in schizophrenia consistent with medial temporal lobe dysfunction. Neuroimaging studies have identified medial temporal lobe abnormalities that have been correlated with clinical features. Postmortem findings in the hippocampus and entorhinal cortex have included differences in neuron density, size, and arrangement; abnormalities in synapse-related proteins; alterations in monoaminergic and glutamatergic innervation and receptor distribution; and abnormalities in the expression of cytoskeletal proteins. These findings appear most consistent with models of aberrant development of medial temporal lobe structures in schizophrenia.

PMID:
9276847
DOI:
10.1176/jnp.9.3.460
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center