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Parasitol Res. 1997;83(7):706-11.

Experimental infection of nude mice as a model for Sarcocystis neurona-associated encephalitis.

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Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616-8745, USA.


The development of a rodent model for the study of Sarcocystis neurona encephalitis is described. Animal models have been developed for a number of protozoal parasites; however, no such model exists for S. neurona. The approach used in this study is similar to that employed for other closely related protozoal parasites such as Neospora caninum and Toxoplasma gondii. A time course of infection was examined, and histopathology, immunohistochemistry, and parasite isolation were used to examine the pathogenesis and follow the infection from 1 to 6 weeks postinoculation. S. neurona was associated with the development of encephalitis in these mice, and the immune status determined the susceptibility of these mice to S. neurona-associated encephalitis.

[Indexed for MEDLINE]

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