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Pacing Clin Electrophysiol. 1997 Aug;20(8 Pt 1):2024-5.

Quinine may trigger torsades de pointes during astemizole therapy.

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University of Texas at Austin College of Pharmacy, USA.


Because of serious cardiovascular events, warnings against concomitant use of certain medications with the use of antihistamine (HismanalR have been published and added to product labeling. Quinine, the optical isomer to quinidine, is included in these warnings. We present the case of a patient with only mild electrolyte disturbances who experienced an episode of torsades de pointes after a single dose of quinine while taking astemizole.

[Indexed for MEDLINE]

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