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FEBS Lett. 1997 Jul 14;411(2-3):327-34.

BIT, an immune antigen receptor-like molecule in the brain.

Author information

1
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan. ssano@libra.ls.m-kagaku.co.jp

Abstract

We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containing two tyrosine-based activation motifs (TAM) that are variants of the antigen receptor signaling motifs. The overall structure is similar to those of immune antigen receptors. This molecule, BIT (brain immunoglobulin-like molecule with TAMs), is a major endogenous substrates of brain tyrosine kinases in vitro. Cerebral cortical neurons could extend their neurites on BIT-coated substrate and anti-BIT monoclonal antibody specifically inhibited the effect. These findings and our recent study concerning BIT signal transduction mechanism suggest that BIT, an immune antigen receptor-like molecule of the brain, functions as a membrane signaling molecule that may participate in cell-cell interaction.

PMID:
9271230
DOI:
10.1016/s0014-5793(97)00724-2
[Indexed for MEDLINE]
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