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Pediatr Infect Dis J. 1997 Aug;16(8):763-7.

Prospective study of fluconazole therapy in systemic neonatal fungal infection.

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Department of Paediatrics, Baragwanath Hospital, University of the Witwatersrand, South Africa.



Standard neonatal systemic antifungal therapy with amphotericin B and flucytosine can be associated with toxicity, drug resistance and the need for prolonged venous access. There is consequently a need for alternative treatment options.


To assess the efficacy and safety of fluconazole in the treatment of systemic neonatal fungal infections.


Open, nonrandomized evaluation of fluconazole treatment in 20 consecutively enrolled neonates with systemic fungal infection.


Clinical and microbiologic cure was achieved in 12 of 19 (63%) of infants treated. One additional infant received prior amphotericin B therapy and is included for assessment of side effects. One infant with Torulopsis glabrata infection failed treatment. Six infants died of Gram-negative bacterial infection and other intercurrent medical problems.


Fluconazole appeared to be safe and effective for treatment of systemic candidal infection in the neonate although more data are required in very low birth weight infants.

[Indexed for MEDLINE]

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