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J Am Acad Dermatol. 1997 Aug;37(2 Pt 1):227-30.

Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications.

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1
Dermatopharmacology Study Center, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

BACKGROUND:

Previous studies have documented reversal of long-term photodamage with once-daily applications of topical tretinoin.

OBJECTIVE:

Our purpose was to assess the effectiveness of tretinoin emollient cream in maintaining improvement in photodamage with a reduced frequency of applications.

METHODS:

A total of 126 subjects who completed 48 weeks of once-daily treatment with tretinoin emollient cream 0.05% were enrolled for an additional 24 weeks of tretinoin once weekly, three times weekly, or no therapy.

RESULTS:

The clinical improvement observed during 48 weeks of once-daily treatment was sustained with three-times weekly applications and to a lesser extent with once-weekly dosing, whereas effects tended to regress in subjects off therapy. The overall incidence of adverse events in the skin and subcutaneous tissues appeared to vary with dose frequency.

CONCLUSION:

After 48 weeks of once-daily treatment, the continued use of tretinoin emollient cream 0.05% at a dose of three times per week maintains and, in some cases, may further enhance improvement in photodamage. Discontinuation of therapy results in some reversal of beneficial effects.

PMID:
9270508
DOI:
10.1016/s0190-9622(97)80129-6
[Indexed for MEDLINE]

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