Effect of photodynamic therapy on selected laboratory values of patients with nasopharyngeal carcinoma

Ann Otol Rhinol Laryngol. 1997 Aug;106(8):680-2. doi: 10.1177/000348949710600812.

Abstract

We determined pre- and post-photodynamic therapy (PDT) serum levels of soluble interleukin-2 receptor (SIL-2R) and interleukin-2 (IL-2), as well as activity of natural killer (NK) cells, among 24 patients with either persistent or recurrent nasopharyngeal carcinoma (NPC), using a double-antibody sandwich technique, tritiated thymidine-deoxyribonucleoside incorporation, and iodine 125-uridine-deoxyribonucleoside release techniques, respectively. The results showed that the post-PDT serum level of SIL-2R had significantly declined (p < .0005), while that of IL-2 and the NK cell activity had significantly increased (p < .0005), compared with pre-PDT values, suggesting an immunoenhancing effect of PDT on NPC patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell / drug therapy*
  • Carcinoma, Squamous Cell / immunology
  • Female
  • Hematoporphyrins / therapeutic use
  • Humans
  • Interleukin-2 / blood
  • Killer Cells, Natural / immunology
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / drug therapy*
  • Nasopharyngeal Neoplasms / immunology
  • Photochemotherapy*
  • Radiation-Sensitizing Agents / therapeutic use
  • Receptors, Interleukin-2 / blood

Substances

  • Hematoporphyrins
  • Interleukin-2
  • Radiation-Sensitizing Agents
  • Receptors, Interleukin-2
  • photocarcinorin