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Trends Biochem Sci. 1997 Aug;22(8):307-12.

Distinct and specific functions of cGMP-dependent protein kinases.

Author information

1
University of W├╝rzburg, Germany. slohmann@klin-biochem

Abstract

cGMP-dependent protein kinases I and II conduct signals from widespread signaling systems. Whereas the type I kinase mediates numerous effects of natriuretic peptides and nitric oxide in cardiovascular cells, the type II kinase transduces signals from the Escherichia coli heat-stable enterotoxin, STa, and from the endogenous intestinal peptide, guanylin, stimulating Cl- conductance of the cystic fibrosis transmembrane conductance regulator (CFTR). Although the two kinases may be interchangeable for several functions, CFTR regulation specifically requires the type II kinase.

PMID:
9270304
DOI:
10.1016/s0968-0004(97)01086-4
[Indexed for MEDLINE]

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