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Trends Biochem Sci. 1997 Aug;22(8):299-306.

Caspases: killer proteases.

Author information

1
Department of Biochemistry and Molecular Biology, Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Inc., Pointe Claire-Dorval, Quebec, Canada.

Abstract

Caspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key and central role that these enzymes play in a biochemical cell-suicide pathway has been conserved throughout the evolution of multicellular eukaryotes.

PMID:
9270303
DOI:
10.1016/s0968-0004(97)01085-2
[Indexed for MEDLINE]

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