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Genomics. 1997 Aug 1;43(3):278-84.

Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.

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Department of Genetics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA.


Rat CL-6 is the most highly insulin-induced gene in a liver cell line and is expressed in proliferating liver during regeneration and development. CL-6 is now denoted INSIG1 (insulin-induced gene 1). Human INSIG1 was isolated and found to be 80% identical to the rat gene within the translated region. It was located on human chromosome 7 within band q36. The human INSIG1 promoter conferred a high level of expression in both liver and fibroblast cell lines. INSIG1 expression was upregulated at the transcriptional level in rat regenerating liver and induced in a model of murine adipocyte differentiation, suggesting that INSIG1 may play a role in growth and differentiation of tissues involved in metabolic control.

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