Send to

Choose Destination
Virology. 1997 Aug 4;234(2):304-8.

Type 1 HERV-K genome is spliced into subgenomic transcripts in the human breast tumor cell line T47D.

Author information

Department of Oncology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467, USA.


Two types of HERV-K genomes exist which differ in the absence (type 1) or the presence (type 2) of a sequence of 292 nucleotides between the putative pol and env genes. Previously published results from teratocarcinoma cell studies had firmly concluded that the type 1 HERV-K genome was defective in splicing and that only the nondeleted type 2 HERV-K genome containing the 292-nucleotide sequence was capable of being spliced. We now show that in the T47D human breast tumor cell line it is the type 1 HERV-K genome, and not the type 2, which is spliced to subgenomic transcripts.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center