Send to

Choose Destination
Synapse. 1997 Sep;27(1):79-82.

Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex.

Author information

Department of Psychiatry, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106-4935, USA.


The distribution of 5-HT2A receptors in rat cortex was evaluated using newly developed antibodies. Each of three antibodies tested identified an identical pattern of 5-HT2A-like immunoreactivity (5-HT2A-li) in rat cortex with 5-HT2A-li showing a widespread distribution. The majority of 5-HT2A-li cells displayed a pyramidal morphology. While a minority, some cortical neurons with a bipolar morphology displayed 5-HT2A-li as well. Dual-label fluorescence confocal microscopic studies with a 5-HT2A antibody and a mouse monoclonal antibody to parvalbumin, a marker of a subset of gamma aminobutyric acid (GABA)ergic interneurons in the cortex, demonstrated that although some cells expressing 5-HT2A-li were interneurons, most were not.

Supplemental Content

Loading ...
Support Center