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Arch Neurol. 1997 Aug;54(8):1012-5.

Serum angiotensin-converting enzyme in multiple sclerosis.

Author information

1
Department of Neurology, University of Pennsylvania, Philadelphia 19104-4283, USA.

Abstract

OBJECTIVE:

To determine the extent and significance of serum angiotensin-converting enzyme (ACE) elevation in multiple sclerosis (MS) and the correlation between serum ACE activity and clinical and magnetic resonance imaging (MRI) indicators of disease activity.

DESIGN:

A retrospective cross-sectional study of 45 consecutive patients with clinically definite MS and a longitudinal study of 30 additional patients with clinically definite MS involved in a long-term study of neurologic function and MRI in MS.

SETTING:

Comprehensive MS center of a tertiary care university hospital.

SUBJECTS:

A total of 75 patients with clinically definite MS and 31 healthy controls.

METHODS:

Serum ACE activity was measured using a spectrophotometric assay and correlated with clinical indicators of disease activity and with total cerebral MS lesion volume measured by MRI.

RESULTS:

An elevated ACE activity was found in 17 (23%) of 75 patients with MS as compared with 2 (6%) of 31 healthy controls. Changes in serum ACE activity correlated with changes in total plaque volume on MRI.

CONCLUSIONS:

Serum ACE activity may be an indicator of disease activity in longitudinal analysis. Also, elevated ACE activity in a patient with otherwise typical MS need not raise suspicions of alternative diagnoses.

PMID:
9267976
[Indexed for MEDLINE]

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