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Biol Neonate. 1997;72(2):71-5.

Human meconium has potent antioxidative properties.

Author information

1
Department of Pediatrics, University of Turku, Finland.

Abstract

In vitro the antioxidative capacity of pooled and lyophilized human meconium, measured by chemiluminescence, was compared to that of three potent antioxidants: vitamin C, a vitamin E analogue and a synthetic antioxidant, butylated hydroxytoluene. Meconium showed a significant superoxide trapping and peroxidation prevention capacity, but its capacity to trap peroxyl radicals was minor. These effects of meconium were possibly due to bilirubin and ubiquinol-10, both found in high concentrations in meconium. It is speculated that human meconium may have a physiological role as an important endogenous antioxidant during perinatal transition.

PMID:
9267672
DOI:
10.1159/000244468
[Indexed for MEDLINE]

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