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Ann Neurol. 1997 Aug;42(2):261-4.

Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects.

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1
Neurology Service, Veterans Affairs Medical Center, San Diego, CA 92161, USA.

Abstract

The activities of complex I and complex II/III in platelet mitochondria are reduced in patients with early, untreated Parkinson's disease. Coenzyme Q10 is the electron acceptor for complex I and complex II. We found that the level of coenzyme Q10 was significantly lower in mitochondria from parkinsonian patients than in mitochondria from age- and sex-matched control subjects and that the levels of coenzyme Q10 and the activities of complex I and complex II/III were significantly correlated.

PMID:
9266740
DOI:
10.1002/ana.410420221
[Indexed for MEDLINE]
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