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Curr Opin Struct Biol. 1997 Aug;7(4):566-73.

Channel-forming toxins: tales of transformation.

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Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.


Channel-forming bacterial toxins undergo a series of remarkable changes in solubility, oligomerization state, structure and dynamics during the processes of membrane binding, assembly, membrane insertion and channel formation. Recent high-resolution crystal structures of channel-forming toxins, in both water-soluble and membrane-bound, channel-formed states, have brought a wealth of new information to bear on issues of structure, mechanism and function.

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