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Curr Opin Struct Biol. 1997 Aug;7(4):486-94.

Modeling transmembrane helical oligomers.

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Department of Biochemistry and Biophysics, Johnson Research Foundation, University of Pennsylvania School of Medicine, Philadelphia 19104-6059, USA.


Recently, methods for the analysis and design of water-soluble, oligomeric bundles of alpha helices, including coiled coils, have reached a high level of sophistication. These same methods may now be applied to transmembrane helical bundles. Studies of the transmembrane domains of glycophorin, phospholamban, and the M2 protein from influenza A virus exemplify this general approach.

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