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Ann Intern Med. 1997 Aug 15;127(4):289-93.

Reduced plasma concentrations of antituberculosis drugs in patients with HIV infection.

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1
University of Ottawa, Ottawa General Hospital, Ontario, Canada.

Abstract

BACKGROUND:

Reports suggest that antituberculosis drugs are malabsorbed in patients with advanced HIV disease.

OBJECTIVE:

To evaluate the pharmacokinetics of antituberculosis agents in HIV-seropositive patients at different stages of disease.

DESIGN:

Parallel study.

SETTING:

Two hospital outpatient clinics.

PARTICIPANTS:

12 healthy volunteers, 12 patients with asymptomatic HIV disease, 12 patients with symptomatic HIV disease, and 12 patients with symptomatic HIV disease and diarrhea.

MEASUREMENTS:

Drug plasma concentrations were measured over 24 hours on day 4 of concurrent therapy.

INTERVENTION:

Oral isoniazid (300 mg/d), rifampin (600 mg/d), pyrazinamide (1000 mg/d), and ethambutol (1000 mg/d).

RESULTS:

Reduced total drug exposure to rifampin and pyrazinamide was associated with D-xylose malabsorption in persons with HIV infection or AIDS. Peak drug exposure to isoniazid was lower in patients with diarrhea.

CONCLUSIONS:

Reduced total drug exposure may be related to malabsorption in persons with HIV infection or AIDS.

[Indexed for MEDLINE]

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