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Bioessays. 1997 Aug;19(8):673-82.

Epithelial differentiation in Drosophila.

Author information

1
Department of Zoology, University of Toronto, Ontario, Canada. utepass@zoo.utoronto.ca

Abstract

Our understanding of epithelial development in Drosophila has been greatly improved in recent years. Two key regulators of epithelial polarity, Crumbs and DE-cadherin, have been studied at the genetic and molecular levels and a number of additional genes are being analyzed that contribute to the differentiation of epithelial cell structure. Epithelial architecture has a profound influence on morphogenetic movements, patterning and cell-type determination. The combination of embryological and genetic/molecular tools in Drosophila will help us to elucidate the complex events that determine epithelial cell structure and how they relate to morphogenesis and other developmental processes.

PMID:
9264249
DOI:
10.1002/bies.950190807
[Indexed for MEDLINE]

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