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J Membr Biol. 1997 Aug 1;158(3):177-86.

The molecular physiology of electroneutral cation-chloride cotransport.

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Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA.


The application of molecular biology to the study of electroneutral cation-chloride cotransporters has been extremely successful, resulting in the identification of a new gene family of five membrane proteins. The function, expression, and regulation of these important proteins can increasingly be described in molecular terms. In addition, mutations in two renal cation-chloride transporter genes have been found in patients with Bartter's and Gitelman's syndromes, autosomal recessive disorders of renal salt excretion.

[Indexed for MEDLINE]

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