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Trends Biotechnol. 1997 Aug;15(8):302-7.

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.

Author information

1
Jackson Laboratory, Bar Harbor, ME 04609, USA. lds@aretha.jax.org

Abstract

Spontaneous mouse mutations that cause severe immunodeficiency or autoimmunity are invaluable tools with which to investigate the mammalian immune system. Mutations at the 'motheaten' locus result in severe immunological dysfunction due to disruption of the structural gene encoding Src-homology 2-domain phosphatase-1 (SHP-1). This natural model for a specific protein-tyrosine-phosphatase deficiency is being widely utilized to determine the role of SHP-1 in the negative regulation of multiple signaling pathways in a number of hematopoietic lineages.

PMID:
9263478
DOI:
10.1016/S0167-7799(97)01060-3
[Indexed for MEDLINE]

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