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Trends Microbiol. 1997 Aug;5(8):323-6.

DNA supercoiling and bacterial adaptation: thermotolerance and thermoresistance.

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Dept of Biochemistry and Molecular Biology, New York Medical College, Valhalla 10595, USA.


When bacterial cells are shifted to higher temperatures their degree of DNA supercoiling changes. Topoisomerases are involved in bacterial adaptation to environmental changes requiring rapid shifts in gene expression. This role in heat shock has been elucidated by genetic studies on the Escherichia coli topA gene and its sigma 32-dependent promoter, P1. Other studies have shown that certain gyrA mutants have increased thermoresistance.

[Indexed for MEDLINE]

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