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Curr Opin Cell Biol. 1997 Aug;9(4):477-83.

COPII and secretory cargo capture into transport vesicles.

Author information

1
Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA. Kuehn@mendel.berketey.edu

Abstract

Yeast cylosolic coat proteins (COPII) direct the formation of vesicles from the endoplasmic reticulum. The vesicles selectively capture both cargo molecules and the secretory machinery that is necessary for the fusion of the vesicle with the recipient compartment, the Golgi apparatus. Recent efforts have aimed to understand how proteins are selected for inclusion into these vesicles. A variety of cargo adaptors may concentrate and sort secretory and membrane proteins by direct or indirect interaction with a subset of coat protein subunits.

PMID:
9261052
DOI:
10.1016/s0955-0674(97)80022-1
[Indexed for MEDLINE]

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