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Curr Opin Cell Biol. 1997 Aug;9(4):527-33.

The trans-Golgi network: a late secretory sorting station.

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Division of Hematology, Washington University School of Medicine, St Louis, MO 63110, USA.


Proteins synthesized on membrane-bound ribosomes are transported through the Golgi apparatus and, on reaching the trans-Golgi network, are sorted for delivery to various cellular destinations. Sorting involves the assembly of cytosol-oriented coat structures which preferentially package cargo into vesicular transport intermediates. Recent studies have shed new light on both the molecular machinery involved and the complexity of the sorting processes.

[Indexed for MEDLINE]

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