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Biochim Biophys Acta. 1997 Jul 17;1353(1):13-7.

Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains.

Author information

1
Pharmaceutical Basic Research Laboratories (Aobadai) Japan Tobacco, Inc., Yokohama, Kanagawa. yokoyama@tcrl.jti.co.jp

Abstract

We have isolated a human cDNA clone representing a novel human gene. The predicted 683-amino-acid protein, designated FPM315, contains nine C2H2-type zinc finger motifs and two regions homologous to the LeR domain, a finger-associated structural domain, and the A element of the Kruppel-associated box (KRAB) domain involved in transcriptional repression. The FPM315 mRNAs were expressed in all human tissues so far examined. A cross-species genomic hybridization indicates that the FPM315 gene is highly conserved among eukaryotes. These data suggest that FPM315 might play an important role in basic cellular processes.

PMID:
9256059
DOI:
10.1016/s0167-4781(97)00074-2
[Indexed for MEDLINE]

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