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J Obstet Gynaecol Res. 1997 Jun;23(3):223-30.

The behavior of endometrial hyperplasia: a prospective study. Endometrial Hyperplasia Study Group.

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  • 1Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan.



To clarify the behavior of endometrial hyperplasia in a prospective study.


Fifty-one patients with endometrial hyperplasia were followed up for 6 months. Samples of endometrial tissues were taken by uterine endometrial biopsy every 4 weeks during the first 3 months and at the end of follow-up.


In 69% (35/51) of the patients histological picture of the endometrium became normal during the observation period. The lesions persisted in 17% (6/35) of the patients with simple hyperplasia, in 25% (1/4) of those with complex hyperplasia, in 14% (1/7) of those with simple atypical hyperplasia, and in 80% (4/5) of the patients with complex atypical hyperplasia. In the remaining 3 patients with simple hyperplasia, the lesions progressed to complex atypical hyperplasia by the end of follow-up, after showing a normal endometrium.


Most cases of endometrial hyperplasia, except for complex atypical hyperplasia, disappeared spontaneously within a short period of time.

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