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J Mol Med (Berl). 1997 Jul;75(7):467-9.

The breast cancer gene product TSG101: a regulator of ubiquitination?

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University of Oxford, Fibrinolysis Research Unit, UK.


Sequence analysis is a powerful tool to obtain structural and functional information about genes and their products. Here we show that TSG101, a gene subjected to somatic mutations in breast cancer, contains an amino terminal domain that is a homologue of ubiquitin conjugating enzymes (UBCs) and not, as previously proposed, DNA-binding domains. As the UBC active site residue is replaced in the TSG101 sequence in a similar manner to several other members of the UBC family, we propose a role for TSG101 in regulating the ubiquitination of short-lived gene products.

[Indexed for MEDLINE]

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