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Nat Struct Biol. 1997 Aug;4(8):615-8.

Crystal structure of a trapped phosphoenzyme during a catalytic reaction.

Abstract

The crystal structure of the fructose-2,6-bisphosphatase domain trapped during the reaction reveal a phosphorylated His 258, and a water molecule immobilized by the product, fructose-6-phosphate. The geometry suggests that the dephosphorylation step requires prior removal of the product for an 'associative in-line' phosphoryl transfer to the catalytic water.

PMID:
9253407
[Indexed for MEDLINE]
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