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Neuropsychopharmacology. 1997 Aug;17(2):82-91.

Adenosine A2A agonists: a potential new type of atypical antipsychotic.

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1
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.

Abstract

The systemic intraperitoneal (i.p.) administration of the adenosine A2A agonist CGS 21680 was found to dose-dependently antagonize spontaneous and amphetamine-induced (1 mg/kg i.p.) motor activity with similar ED50 values (about 0.2 mg/kg). The ratios between the ED50 values for induction of catalepsy and for antagonizing amphetamine-induced motor activity for CGS 21680, haloperidol, and clozapine were 12, 2, and > 30, respectively. Furthermore, CGS 21680 was comparably much stronger than haloperidol or clozapine at antagonizing the motor activity induced by phencyclidine (2 mg/kg subcutaneously) than motor activity induced by amphetamine (1 mg/kg i.p.). In conclusion, the present results show a clear "atypical" antipsychotic profile of the adenosine A2A agonist CGS 21680 in animal models.

PMID:
9252983
DOI:
10.1016/S0893-133X(97)00033-X
[Indexed for MEDLINE]
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