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Forensic Sci Int. 1997 Aug 4;88(2):133-40.

Gas chromatographic/mass spectrometric determination of lysergic acid diethylamide (LSD) in serum samples.

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Institute of Legal Medicine, Rheinische Friedrich-Wilhelms-University, Bonn, Germany.


A sensitive method for the detection and quantification of lysergic acid diethylamide (LSD) in serum samples is described. After liquid-liquid extraction the trimethylsilyl derivative of LSD is detected by gas chromatography-mass spectrometry. Experiments with spiked samples resulted in a recovery of 76%, the coefficient of variation was 9.3%. Excellent linearity was obtained over the range 0.1-10 ng ml-1. Additionally experiments demonstrating the light sensitivity of LSD are presented together with casuistics.

[Indexed for MEDLINE]

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